In present research work the effect of climate change over the humidex in Iran is analyzed. From this research, we can conclude that the PDIAQ index showed a special sensibility to changes in temperature and relative humidity, hence, it can be an interesting tool, may be even better than the humidex to show the expected effect of climate change in perception of air quality. Thus, it was found that the humidex expected in the future will be more elevated than that in the preceding period and, on the other hand, the PDWRC has clearly reached a lower value than in the preceding period. The same effects, other than those using the earlier indexes in a more detailed manner, were observed with the PDIAQ. This index showed a higher sensitivity to variations in temperature and relative humidity, than the humidex. Finally, the main results obtained must be considered at the time of design and during construction of future buildings, since buildings that are being constructed today will be occupied in the future years of the 2100s.