Deregulated type I IFN response in TREX1-associated familial chilblain lupus

J Invest Dermatol. 2014 May;134(5):1456-1459. doi: 10.1038/jid.2013.496. Epub 2013 Nov 22.

Affiliations

¹ Institute for Immunology, Technical University Dresden, Dresden, Germany.
² Department of Dermatology, University Hospital, Technical University Dresden, Dresden, Germany.
³ Department of Pediatrics, University Hospital, Technical University Dresden, Dresden, Germany.
⁴ Department of Dermatology, University Hospital, Technical University Dresden, Dresden, Germany. Electronic address: Claudia.guenther@uniklinikum-dresden.de.

PMID: 24270665
DOI: 10.1038/jid.2013.496

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoimmunity / genetics*
Autoimmunity / immunology
Chilblains / genetics*
Chilblains / immunology
Chilblains / metabolism
Child
Exodeoxyribonucleases / genetics*
Exodeoxyribonucleases / immunology
Exodeoxyribonucleases / metabolism
Heterozygote
Humans
Interferon Type I / immunology
Interferon Type I / metabolism*
Lupus Erythematosus, Cutaneous / genetics*
Lupus Erythematosus, Cutaneous / immunology
Lupus Erythematosus, Cutaneous / metabolism
Mice
Mice, Knockout
Phosphoproteins / genetics*
Phosphoproteins / immunology
Phosphoproteins / metabolism

Substances

Interferon Type I
Phosphoproteins
Exodeoxyribonucleases
three prime repair exonuclease 1

Supplementary concepts

Chilblain lupus 1