Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis

Ming-Luen Lee; Hsiu-Ju Yen; Shu-Jen Chen; Giun-Yi Hung; Pei-Chen Tsao; Wen-Jue Soong

doi:10.1016/j.pedneo.2013.06.009

Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis

Pediatr Neonatol. 2016 Apr;57(2):149-52. doi: 10.1016/j.pedneo.2013.06.009. Epub 2013 Oct 23.

Authors

Ming-Luen Lee¹, Hsiu-Ju Yen², Shu-Jen Chen¹, Giun-Yi Hung¹, Pei-Chen Tsao³, Wen-Jue Soong³

Affiliations

¹ Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
² Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: hjyen2@vghtpe.gov.tw.
³ Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC; Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

PMID: 24269860
DOI: 10.1016/j.pedneo.2013.06.009

Abstract

Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms of respiratory distress. She gradually developed clinical manifestations of JMML that mimicked neonatal sepsis. Three weeks after birth, JMML was diagnosed. This is the first reported case of JMML presenting in a premature infant in Taiwan.

Keywords: juvenile myelomonocytic leukemia; newborn; premature neonate.

Publication types

Case Reports

MeSH terms

Diagnosis, Differential
Female
Humans
Infant, Newborn
Infant, Premature
Leukemia, Myelomonocytic, Juvenile / diagnosis*
Neonatal Sepsis / diagnosis
Respiratory Distress Syndrome, Newborn / etiology