Abstract
Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
Keywords:
17β-Estradiol; Energy homeostasis; NPY/AgRP; POMC.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Agouti-Related Protein / metabolism
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Animals
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Body Temperature Regulation
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Eating*
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Energy Metabolism
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Estradiol / metabolism*
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Estradiol / pharmacology
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Estrogen Receptor alpha / metabolism
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Feedback, Physiological
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GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
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Homeostasis
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Humans
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Hypothalamus / cytology
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Hypothalamus / metabolism*
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Neurons / drug effects
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Neurons / metabolism*
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Neuropeptide Y / metabolism
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Pro-Opiomelanocortin
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Signal Transduction
Substances
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Agouti-Related Protein
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Estrogen Receptor alpha
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Neuropeptide Y
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Estradiol
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Pro-Opiomelanocortin
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GTP-Binding Protein alpha Subunits, Gq-G11