Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons

Steroids. 2014 Mar:81:31-5. doi: 10.1016/j.steroids.2013.11.007. Epub 2013 Nov 20.

Abstract

Two populations of cells within the hypothalamus exert opposite actions on food intake: proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17β-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.

Keywords: 17β-Estradiol; Energy homeostasis; NPY/AgRP; POMC.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Agouti-Related Protein / metabolism
  • Animals
  • Body Temperature Regulation
  • Eating*
  • Energy Metabolism
  • Estradiol / metabolism*
  • Estradiol / pharmacology
  • Estrogen Receptor alpha / metabolism
  • Feedback, Physiological
  • GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
  • Homeostasis
  • Humans
  • Hypothalamus / cytology
  • Hypothalamus / metabolism*
  • Neurons / drug effects
  • Neurons / metabolism*
  • Neuropeptide Y / metabolism
  • Pro-Opiomelanocortin
  • Signal Transduction

Substances

  • Agouti-Related Protein
  • Estrogen Receptor alpha
  • Neuropeptide Y
  • Estradiol
  • Pro-Opiomelanocortin
  • GTP-Binding Protein alpha Subunits, Gq-G11