Molecular pathology techniques

Abstract

Molecular pathology techniques have matured considerably over the last decade. New technologies have provided increased sensitivity for improved diagnostic capacity. Furthermore, novel methodologies have matured to interrogate nucleic acid and protein signatures effectively to aid in elucidating the pathophysiology of disease in addition to diagnosis, prognosis, and therapeutic monitoring for patient management. Here general molecular techniques used in the molecular pathology laboratory as they are used for clinical applications are described.

Keywords: FISH; Hybrid capture; Methodology; Molecular pathology; RFLP; RT-PCR; SNP.