Behavioral disorders in Parkinson's disease: the role of dopamine

Francesca Antonelli; Antonio P Strafella

doi:10.1016/S1353-8020(13)70005-1

Behavioral disorders in Parkinson's disease: the role of dopamine

Parkinsonism Relat Disord. 2014 Jan:20 Suppl 1:S10-2. doi: 10.1016/S1353-8020(13)70005-1.

Authors

Francesca Antonelli¹, Antonio P Strafella

Affiliation

¹ Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Parkinson's Disease and Movement Disorders Unit, Neurology Clinic, Hospital Clinic Universitari, University of Barcelona, Barcelona, Spain.

PMID: 24262157
DOI: 10.1016/S1353-8020(13)70005-1

Abstract

Dopaminergic neurons play a major role in controlling movement and behavior. In Parkinson's disease (PD), dopaminergic denervation is responsible for a number of motor and non-motor symptoms including tremor, rigidity and akinesia and as well apathy, impulsivity and other behavioral complications frequently reported in these patients. In this review, we will summarize the possible proposed dopaminergic mechanisms responsible for these complications in PD, focusing mainly on the role of this neurotransmitter in behavioral symptoms.

Keywords: Behavioral disorder; Dopamine; Impulsivity; Neuroimaging.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Behavioral Symptoms / etiology*
Behavioral Symptoms / metabolism*
Dopamine / metabolism*
Humans
Parkinson Disease / complications*

Substances

Dopamine

Grants and funding

MOP 117891/Canadian Institutes of Health Research/Canada