Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain

Cheng-Hsun Wu; Yi-Ping Chen; Si-Han Wu; Yann Hung; Chung-Yuan Mou; Richard P Cheng

doi:10.1021/am4039882

Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain

ACS Appl Mater Interfaces. 2013 Dec 11;5(23):12244-8. doi: 10.1021/am4039882. Epub 2013 Nov 21.

Authors

Cheng-Hsun Wu¹, Yi-Ping Chen, Si-Han Wu, Yann Hung, Chung-Yuan Mou, Richard P Cheng

Affiliation

¹ Department of Chemistry, National Taiwan University , Taipei 10617, Taiwan.

PMID: 24261815
DOI: 10.1021/am4039882

Abstract

Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arginine / chemistry*
Endocytosis
HeLa Cells
Humans
Membrane Transport Proteins / chemistry*
Microscopy, Confocal
Nanoparticles*
Silicon Dioxide / chemistry*

Substances

Membrane Transport Proteins
Silicon Dioxide
Arginine
peptide permease