Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms

Nat Prod Res. 2014;28(3):144-9. doi: 10.1080/14786419.2013.856908. Epub 2013 Nov 21.

Abstract

Two new ceramides, (3S,4S,5R)-3-octadecanoylamino-4-hydroxy-5-dodecane-2,3,4,5-tetrahydrofuran (1) and (3S,4S,5R)-3-[(2R)-2-hydroxyhexacosanoylamino]-4-hydroxy-5-[(4E)-dodecane-4-ene]-2,3,4,5-tetrahydrofuran (2), together with eight known compounds, eleutheroside A (3), eleutheroside B (4), eleutheroside E (5), 7-hydroxy-6-methoxy-coumarin (6), 6,7-dimethoxycoumarin (7), 5α,8α-epidioxyergosta-6,22-dien-3-ol (8), stigmasterol (9) and rutin (10), were isolated from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Their structures were elucidated by means of physicochemical properties and spectroscopic methods (1D, 2D NMR and MS).

MeSH terms

  • Ceramides / chemistry
  • Ceramides / isolation & purification*
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Drugs, Chinese Herbal / chemistry
  • Eleutherococcus / chemistry*
  • Fruit / chemistry
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Lignans / chemistry
  • Lignans / isolation & purification
  • Nuclear Magnetic Resonance, Biomolecular
  • Rutin / chemistry
  • Rutin / isolation & purification
  • Stereoisomerism
  • Stigmasterol / chemistry
  • Stigmasterol / isolation & purification

Substances

  • (3S,4S,5R)-3-((2R)-2-hydroxyhexacosanoylamino)-4-hydroxy-5-((4E)-dodecane-4-ene)-2,3,4,5-tetrahydrofuran
  • (3S,4S,5R)-3-octadecanoylamino-4-hydroxy-5-dodecane-2,3,4,5-tetrahydrofuran
  • Ceramides
  • Coumarins
  • Drugs, Chinese Herbal
  • Glucosides
  • Lignans
  • Rutin
  • eleutheroside E
  • Stigmasterol
  • scoparone