Abstract
In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.76-1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor. All the novel compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR, and elemental analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Azo Compounds / chemical synthesis*
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Azo Compounds / chemistry
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Azo Compounds / pharmacology*
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Azo Compounds / toxicity
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Cell Death / drug effects
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Cell Line, Tumor
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / toxicity
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Melanins / biosynthesis
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Mice
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Monophenol Monooxygenase / antagonists & inhibitors*
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Monophenol Monooxygenase / metabolism
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Spectrophotometry, Ultraviolet
Substances
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Azo Compounds
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Enzyme Inhibitors
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Melanins
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Monophenol Monooxygenase