Abstract
We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Chlorpropamide / chemical synthesis*
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Copper / chemistry*
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Glyburide / chemical synthesis*
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Hypoglycemic Agents / chemical synthesis*
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Isothiocyanates / chemistry*
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Molecular Structure
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Sulfonamides / chemistry*
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Tolbutamide / chemical synthesis*
Substances
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Hypoglycemic Agents
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Isothiocyanates
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Sulfonamides
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Copper
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Tolbutamide
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Glyburide
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Chlorpropamide