In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

Marta E López-Viseras; Belén Fernández; Sabine Hilfiker; Cristina Sánchez González; Juan Llopis González; Antonio J Calahorro; Enrique Colacio; Antonio Rodríguez-Diéguez

doi:10.1016/j.jinorgbio.2013.10.019

In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

J Inorg Biochem. 2014 Feb:131:64-7. doi: 10.1016/j.jinorgbio.2013.10.019. Epub 2013 Oct 30.

Authors

Marta E López-Viseras¹, Belén Fernández², Sabine Hilfiker³, Cristina Sánchez González⁴, Juan Llopis González⁵, Antonio J Calahorro⁶, Enrique Colacio¹, Antonio Rodríguez-Diéguez¹

Affiliations

¹ Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain.
² Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Avenida del Conocimiento S.N., Armilla, Granada, Spain. Electronic address: belenfernandez@ipb.csic.es.
³ Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Avenida del Conocimiento S.N., Armilla, Granada, Spain.
⁴ Instituto de Nutrición y Tecnología de los Alimentos y Departamento de Fisiología, Campus Cartuja, Universidad de Granada, 18071 Granada, Spain. Electronic address: crissg@ugr.es.
⁵ Instituto de Nutrición y Tecnología de los Alimentos y Departamento de Fisiología, Campus Cartuja, Universidad de Granada, 18071 Granada, Spain.
⁶ Departamento de Química Inorgánica, Universidad de Granada, Avda Fuentenueva s/n, 18071 Granada, Spain. Electronic address: antonio5@ugr.es.

PMID: 24252384
DOI: 10.1016/j.jinorgbio.2013.10.019

Abstract

A novel Zn mononuclear complex with 3-carboxy-pyrazole ligand has been prepared using conventional routes and characterized by X-ray diffraction. The structure consists of discrete neutral [Zn(C6H3N2O2)2(H2O)2] molecules held together by hydrogen interactions. This compound exhibits a potential in vivo antidiabetic activity and the in vitro toxicity can be considered negligible.

Keywords: Antidiabetic activity; Coordination compound; in vitro toxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Body Weight / drug effects
Diabetes Mellitus, Experimental / drug therapy
Eating / drug effects
Hypoglycemic Agents / chemical synthesis
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology*
Male
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacokinetics*
Pyrazoles / chemistry
Rats
Rats, Wistar
X-Ray Diffraction
Zinc / chemistry*

Substances

Hypoglycemic Agents
Organometallic Compounds
Pyrazoles
pyrazole
Zinc