Ni-catalyzed stereoselective arylation of inert C-O bonds at low temperatures

Josep Cornella; Ruben Martin

doi:10.1021/ol4031815

Ni-catalyzed stereoselective arylation of inert C-O bonds at low temperatures

Org Lett. 2013 Dec 20;15(24):6298-301. doi: 10.1021/ol4031815. Epub 2013 Nov 19.

Authors

Josep Cornella¹, Ruben Martin

Affiliation

¹ Institute of Chemical Research of Catalonia (ICIQ) , Av Països Catalans 16, 43007 Tarragona, Spain , and Catalan Institution for Research and Advanced Studies (ICREA) , Passeig Lluïs Companys, 23, 08010 Barcelona, Spain.

PMID: 24252127
DOI: 10.1021/ol4031815

Abstract

A Ni-catalyzed arylation of inert C-O bonds that operates at temperatures as low as -40 °C is described. Unlike other methods for C-O bond cleavage utilizing organometallic species, this protocol operates at low temperatures, thus allowing the presence of sensitive functional groups with exquisite site-selectivity and stereoselectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemical synthesis*
Alcohols / chemistry
Catalysis
Nickel / chemistry*
Organometallic Compounds / chemistry*
Stereoisomerism
Temperature*

Substances

Alcohols
Organometallic Compounds
Nickel