Severe hypersensitivity pneumonitis associated with everolimus therapy for neuroendocrine tumour: a case report

BMC Res Notes. 2013 Nov 18:6:471. doi: 10.1186/1756-0500-6-471.

Abstract

Background: Novel therapeutic agents are currently being investigated for neuroendocrine tumour treatment.

Case presentation: We report here on the case of a patient presenting with hypersensitivity pneumonitis while being treated with everolimus, a mammalian target of rapamycin (mTOR) inhibitor.

Conclusion: Side effects of everolimus should be familiar to clinicians, including nonspecialists, and be monitored carefully to allow for prompt management.

Publication types

  • Case Reports

MeSH terms

  • Alveolitis, Extrinsic Allergic / chemically induced*
  • Alveolitis, Extrinsic Allergic / pathology
  • Antineoplastic Agents / adverse effects*
  • Everolimus
  • Humans
  • Intestine, Small / drug effects
  • Intestine, Small / pathology
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / drug therapy*
  • Neuroendocrine Tumors / pathology
  • Sirolimus / adverse effects
  • Sirolimus / analogs & derivatives*

Substances

  • Antineoplastic Agents
  • Everolimus
  • Sirolimus