Electrostatically driven complexation of liposomes with a star-shaped polyelectrolyte to low-toxicity multi-liposomal assemblies

Alexander A Yaroslavov; Andrey V Sybachin; Olga V Zaborova; Dmitry V Pergushov; Alexander B Zezin; Nikolay S Melik-Nubarov; Felix A Plamper; Axel H E Müller; Frederic M Menger

doi:10.1002/mabi.201300436

Electrostatically driven complexation of liposomes with a star-shaped polyelectrolyte to low-toxicity multi-liposomal assemblies

Macromol Biosci. 2014 Apr;14(4):491-5. doi: 10.1002/mabi.201300436. Epub 2013 Nov 15.

Authors

Alexander A Yaroslavov¹, Andrey V Sybachin, Olga V Zaborova, Dmitry V Pergushov, Alexander B Zezin, Nikolay S Melik-Nubarov, Felix A Plamper, Axel H E Müller, Frederic M Menger

Affiliation

¹ Lomonosov Moscow State University, Chemistry Department, Leninskie Gory 1-3, 119991, Moscow, Russia.

PMID: 24243764
DOI: 10.1002/mabi.201300436

Abstract

Anionic liposomes are electrostatically complexed to a star-shaped cationic polyelectrolyte. Upon complexation, the liposomes retain their integrity and the resulting liposome-star complexes do not dissociate in a physiological solution with 0.15 M NaCl. This provides a multi-liposomal container for possible use as a high-capacity carrier.

Keywords: drug delivery systems; liposomes; phospholipids; polyelectrolytes; star polymers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anions / chemistry
Cations / chemistry*
Drug Delivery Systems*
Electrolytes / chemistry
Electrolytes / therapeutic use
Humans
Liposomes / chemistry*
Liposomes / therapeutic use
Phospholipids / chemistry
Static Electricity*

Substances

Anions
Cations
Electrolytes
Liposomes
Phospholipids