The purpose of this study was to evaluate and compare the bond strengths between resin composite veneer and laser-sintered cobalt-chromium (Co-Cr) alloy with and without retention devices (Laser-R and Laser-N respectively). Cast Co-Cr alloy with and without retention devices (Cast-R and Cast-N respectively) were also prepared for fabrication technique comparison. Disk-shaped Co-Cr alloy specimens were air-abraded with alumina and veneered with a veneering system, Estenia C&B (ES) or Ceramage (CE). After 20,000 thermocycles, tensile testing was performed. Data were analyzed by ANOVA and multiple comparison test. When no retention devices were present, no significant differences were observed between Laser-N/ES and Cast-N/ES, or between Laser- N/CE and Cast-N/CE, but ES exhibited significantly higher bond strength than CE. With retention devices, Laser-R/ES, Cast- R/ES and Laser-R/CE showed no significant differences, and their retention strengths were significantly higher than that of Cast- R/CE. Compared to cast Co-Cr alloy, laser-sintered Co-Cr alloy with retention devices provided better retention durability for resin composite-veneered prostheses.