Formation of oxo-centered trinuclear chromium carboxylate complexes and hydrolysis of Cr3 as established by paramagnetic (2)H NMR spectroscopy

J Inorg Biochem. 2014 Feb:131:12-20. doi: 10.1016/j.jinorgbio.2013.10.012. Epub 2013 Oct 29.

Abstract

Paramagnetic (2)H NMR techniques have been utilized to study the mechanism of formation of the oxo-bridged trinuclear Cr(III) carboxylate assembly [Cr3O(O2CCD3)6(H2O)3](+) from [Cr(H2O)6](3+) and d4-acetic acid. These studies reveal a complex mechanism dominated by the involvement of dinuclear intermediates. The oxo-bridged trinuclear Cr(III) carboxylate assembly [Cr3O(O2CCH2CH3)6(H2O)3](+) has been suggested for use as a chromium nutritional supplement and therapeutic agent as it is readily absorbed and has been proposed to enter cells intact. The paramagnetic (2)H NMR technique has been utilized to follow the stability of this Cr(III) carboxylate assembly in biologically relevant media; its stability is consistent with the assembly being able to enter cells intact.

Keywords: Acetate; Chromium; Cr3; Propionate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetates / chemistry
  • Animals
  • Carboxylic Acids / chemistry*
  • Chromium / blood
  • Chromium / chemistry*
  • Chromium / pharmacokinetics
  • Coordination Complexes / analysis*
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacokinetics
  • Drug Stability
  • Hydrolysis
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Mice, Inbred Strains
  • Muscle, Skeletal / metabolism
  • Rats
  • Rats, Zucker
  • Water

Substances

  • Acetates
  • Carboxylic Acids
  • Coordination Complexes
  • Water
  • Chromium