New synthetic antibiotics for the treatment of Enterococcus and Campylobacter infection

Curr Top Med Chem. 2014;14(1):21-39. doi: 10.2174/1568026613666131113145544.

Abstract

Bacterial resistance to antibiotics, particularly to multiple drug resistant antibiotics, is becoming cause for significant concern. The only really viable course of action is to discover new antibiotics with novel mode of actions. This review focuses on antibiotic resistance mechanisms of Enterococcus and Campylobacter, and new antibacterial agents against Enterococcus and Campylobacter through de novo or semi- synthesis in the period from 2003 until mid- 2013.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Campylobacter / drug effects*
  • Campylobacter Infections / drug therapy
  • Drug Resistance, Bacterial / drug effects*
  • Enterococcus / drug effects*
  • Humans
  • Ketolides / chemistry
  • Ketolides / pharmacology
  • Macrolides / chemistry
  • Macrolides / pharmacology
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology

Substances

  • Anti-Bacterial Agents
  • Ketolides
  • Macrolides
  • Peptides, Cyclic