The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease

Clin Exp Nephrol. 2014 Apr;18(2):238-42. doi: 10.1007/s10157-013-0907-4.

Abstract

Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1-associated kidney disease.

Publication types

  • Review

MeSH terms

  • Apolipoprotein L1
  • Apolipoproteins / blood
  • Apolipoproteins / genetics*
  • Black People / genetics
  • Genetic Variation
  • Humans
  • Lipoproteins, HDL / blood
  • Lipoproteins, HDL / genetics*
  • Polymorphism, Single Nucleotide
  • Renal Insufficiency, Chronic / genetics*
  • Trypanosoma brucei gambiense
  • Trypanosomiasis, African / genetics

Substances

  • APOL1 protein, human
  • Apolipoprotein L1
  • Apolipoproteins
  • Lipoproteins, HDL