Four new sesquiterpene lactones from the stem bark of Illicium burmanicum

Fitoterapia. 2014 Jan:92:194-9. doi: 10.1016/j.fitote.2013.11.001. Epub 2013 Nov 11.

Abstract

Four new sesquiterpene lactones (1), (2), (3), and (4), along with three known sesquiterene, namely, 6,7,10-trihydoxyisodaucane (5), 4β,10β-dihydroxyaromadendrane (6), and sescrassidiol (7) were isolated from the stem bark of Illicium burmanicum. The structures of the new compounds were determined using 1D and 2D NMR, and HRESIMS. The anti-inflammatory activities of these compounds were evaluated by measuring the enzymatic activity of luciferase in NF-κB reporters in a (Luc)-HEK 293 cell line treated with lipopolysaccharide (LPS).

Keywords: Illicium burmanicum; NF-κB; Sesquiterpene lactones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • HEK293 Cells
  • Humans
  • Illicium / chemistry*
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Lipopolysaccharides
  • Molecular Structure
  • Phytotherapy
  • Plant Bark
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Stems
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Lactones
  • Lipopolysaccharides
  • Plant Extracts
  • Sesquiterpenes