Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats

Indian J Exp Biol. 2013 Aug;51(8):606-14.

Abstract

Polyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Animals, Newborn
  • Antiviral Agents / pharmacology
  • Astrocytes / drug effects*
  • Astrocytes / immunology
  • Astrocytes / metabolism
  • Chronic Disease
  • Female
  • Glial Fibrillary Acidic Protein / metabolism
  • Hippocampus / drug effects*
  • Hippocampus / immunology
  • Hippocampus / metabolism
  • Immunoenzyme Techniques
  • Inflammation / chemically induced*
  • Inflammation / immunology
  • Inflammation / pathology
  • Lipopolysaccharides / pharmacology*
  • Microglia / drug effects*
  • Microglia / immunology
  • Microglia / metabolism
  • Poly I-C / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Antiviral Agents
  • Glial Fibrillary Acidic Protein
  • Lipopolysaccharides
  • Poly I-C