Abstract
Polyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Animals, Newborn
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Antiviral Agents / pharmacology
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Astrocytes / drug effects*
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Astrocytes / immunology
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Astrocytes / metabolism
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Chronic Disease
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Female
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Glial Fibrillary Acidic Protein / metabolism
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Hippocampus / drug effects*
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Hippocampus / immunology
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Hippocampus / metabolism
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Immunoenzyme Techniques
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Inflammation / chemically induced*
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Inflammation / immunology
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Inflammation / pathology
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Lipopolysaccharides / pharmacology*
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Microglia / drug effects*
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Microglia / immunology
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Microglia / metabolism
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Poly I-C / pharmacology*
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Rats
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Rats, Sprague-Dawley
Substances
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Antiviral Agents
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Glial Fibrillary Acidic Protein
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Lipopolysaccharides
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Poly I-C