The role of spacers on the self-assembly of DNA aptamer-amphiphiles into micelles and nanotapes

Chem Commun (Camb). 2014 Jan 7;50(2):210-2. doi: 10.1039/c3cc42311e.

Abstract

The self-assembly of single-stranded DNA (ssDNA) aptamer-amphiphiles was influenced by the choice of spacer used to link the hydrophobic tail and aptamer headgroup. Aptamer-amphiphiles without spacers or with hydrophilic spacers formed globular micelles while amphiphiles with hydrophobic spacers formed bilayer nanotapes, which are the first such structures formed by DNA-amphiphiles.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Base Sequence
  • DNA, Single-Stranded / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Micelles*
  • Models, Molecular
  • Surface-Active Agents / chemistry*

Substances

  • Aptamers, Nucleotide
  • DNA, Single-Stranded
  • Micelles
  • Surface-Active Agents