Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential

Fitoterapia. 2014 Jan:92:211-8. doi: 10.1016/j.fitote.2013.10.018. Epub 2013 Nov 9.

Abstract

The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potential was examined. Compounds 1 and 8 prevented elevation of ROS induced by t-BOOH, suggesting the potential activity of these compounds to protect fibroblasts from oxidative stress.

Keywords: Antioxidant activity; Astragalus plumosus var. krugianus; Cycloartane glycosides; Fibroblasts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Astragalus Plant / chemistry*
  • Fibroblasts / drug effects*
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Humans
  • Molecular Structure
  • Oxidative Stress / drug effects*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Skin / cytology
  • Skin / drug effects
  • Skin / metabolism
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Antioxidants
  • Glycosides
  • Plant Extracts
  • Reactive Oxygen Species
  • Triterpenes
  • cycloartane