Preparation and characterization of silicone rubber/nano-copper nanocomposites for use in intrauterine devices

Biomed Mater Eng. 2014;24(1):1269-74. doi: 10.3233/BME-130929.

Abstract

In this work, a novel silicone rubber/nano-copper nanocomposite for use in intrauterine devices (IUDs) was developed. Moreover, the release rate of Cu2+ ions and the water absorption of the prepared nanocomposite were investigated in detail. The results indicate that the release rate of Cu2+ ions and water absorption capability of the silicone rubber/nanocopper nanocomposite increase as the nano-copper content increases. SEM analysis suggested there is a uniform dispersion of nano-copper in the silicone matrix. Further, systematic analysis indicated that the release rate of Cu2+ ions in the prepared nanocomposite-based IUD can be stabilized for months, which is not possible in the case of traditional IUDs.

Keywords: intrauterine devices; nano-copper; nanocomposites; silicone rubber.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Biocompatible Materials / chemistry
  • Copper / administration & dosage
  • Copper / chemistry*
  • Equipment Design
  • Female
  • Humans
  • Intrauterine Devices*
  • Ions
  • Materials Testing
  • Metal Nanoparticles / chemistry
  • Microscopy, Electron, Scanning
  • Nanocomposites / chemistry*
  • Silicone Elastomers / chemistry*
  • Time Factors
  • Uterus / pathology
  • Water / chemistry

Substances

  • Biocompatible Materials
  • Ions
  • Silicone Elastomers
  • Water
  • Copper