Change in refractive index of muscle tissue during laser-induced interstitial thermotherapy

Na Chen; Meimei Chen; Shupeng Liu; Qiang Guo; Zhenyi Chen; Tingyun Wang

doi:10.3233/BME-130872

Change in refractive index of muscle tissue during laser-induced interstitial thermotherapy

Biomed Mater Eng. 2014;24(1):807-13. doi: 10.3233/BME-130872.

Authors

Na Chen¹, Meimei Chen, Shupeng Liu, Qiang Guo, Zhenyi Chen, Tingyun Wang

Affiliation

¹ Key Lab of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China.

PMID: 24211967
DOI: 10.3233/BME-130872

Abstract

This paper presents a long-period fiber-grating (LPG) based Michelson interferometric refractometry to monitor the change in refractive index of porcine muscle during laser-induced interstitial thermotherapy (LITT). As the wavelength of RI interferometer alters with the change in refractive index around the probe, the LPG based refractometry is combined with LITT system to measure the change in refractive index of porcine muscle when irradiated by laser. The experimental results show the denaturation of tissue alters the refractive index significantly and the LPG sensor can be applied to monitor the tissue state during the LITT.

Keywords: Michelson interferometer; Refractive index; laser-induced interstitial thermotherapy; long-period fiber grating.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Animals
Hyperthermia, Induced*
Interferometry
Lasers*
Muscle, Skeletal / pathology*
Refractometry*
Swine
Temperature