Risk factors for multidrug-resistant bacteremia in hospitalized cancer patients with febrile neutropenia: a cohort study

Am J Infect Control. 2014 Jan;42(1):74-6. doi: 10.1016/j.ajic.2013.06.025. Epub 2013 Nov 8.

Abstract

We conducted a prospective cohort study in a single tertiary hospital with the aim of assessing predictors of multidrug-resistant bacteremia in 307 cases of febrile neutropenia in adult patients with cancer. On multivariate analysis using stepwise logistic regression, age (P = .009), duration of neutropenia (P = .022), and presence of an indwelling central venous catheter (P = .022) were associated with bloodstream infection by multidrug-resistant bacteria.

Keywords: Bacterial; Drug resistance; Fever; Immunocompromised host.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteremia / epidemiology*
  • Bacteria / drug effects*
  • Bacteria / isolation & purification*
  • Cohort Studies
  • Drug Resistance, Multiple, Bacterial*
  • Febrile Neutropenia / complications*
  • Febrile Neutropenia / epidemiology*
  • Female
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / therapy
  • Prospective Studies
  • Risk Factors
  • Tertiary Care Centers
  • Young Adult