Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: case report and review of literature

J Egypt Natl Canc Inst. 2013 Dec;25(4):231-5. doi: 10.1016/j.jnci.2013.07.001. Epub 2013 Aug 6.

Abstract

Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. A brief review of the literature is also presented.

Keywords: Auto-immune antibodies; Diffuse large B-cell lymphoma; Gastric lymphoma; Paraneoplastic cerebellar degeneration; Paraneoplastic neurological disorders; Rituximab.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Cyclophosphamide / therapeutic use
  • Diagnosis, Differential
  • Doxorubicin / therapeutic use
  • Gastroscopes
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Male
  • Middle Aged
  • Paraneoplastic Cerebellar Degeneration / diagnosis*
  • Positron-Emission Tomography
  • Prednisone / therapeutic use
  • Rituximab
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / drug therapy
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Vincristine / therapeutic use

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone