Full genome of influenza A (H7N9) virus derived by direct sequencing without culture

Emerg Infect Dis. 2013 Nov;19(11):1881-4. doi: 10.3201/eid1911.130664.

Abstract

An epidemic caused by influenza A (H7N9) virus was recently reported in China. Deep sequencing revealed the full genome of the virus obtained directly from a patient's sputum without virus culture. The full genome showed substantial sequence heterogeneity and large differences compared with that from embryonated chicken eggs.

Keywords: H7N9; avian-origin; culture-free; deep sequencing; direct sequencing; influenza; influenza A virus; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • China
  • Female
  • Genome, Viral*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Influenza A Virus, H7N9 Subtype / classification
  • Influenza A Virus, H7N9 Subtype / genetics*
  • Influenza A Virus, H7N9 Subtype / isolation & purification
  • Influenza, Human / epidemiology
  • Influenza, Human / virology
  • Middle Aged
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Analysis, DNA
  • Sputum / virology

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus

Associated data

  • GENBANK/KF226105
  • GENBANK/KF226106
  • GENBANK/KF226107
  • GENBANK/KF226108
  • GENBANK/KF226109
  • GENBANK/KF226110
  • GENBANK/KF226111
  • GENBANK/KF226112
  • GENBANK/KF226113
  • GENBANK/KF226114
  • GENBANK/KF226115
  • GENBANK/KF226116
  • GENBANK/KF226117
  • GENBANK/KF226118
  • GENBANK/KF226119
  • GENBANK/KF226120
  • GENBANK/KF278742
  • GENBANK/KF278743
  • GENBANK/KF278744
  • GENBANK/KF278745
  • GENBANK/KF278746
  • GENBANK/KF278747
  • GENBANK/KF278748
  • GENBANK/KF278749