Abstract
Of two related Macaca species, the rhesus (M. mulatta), acquires opiate tolerance and dependence more readily than the cynomolgus (M. fascicularis). In the cynomolgus, mu-opiate receptors were significantly fewer in the caudate nucleus and globus pallidus; delta-sites were fewer in the thalamus. kappa-Sites showed no species difference. The levels of [Met5]enkephalin, substance P and dynorphin B in various brain areas were comparable. On the other hand, receptor-assayed endorphin activity was higher in CSF of cynomolgus than rhesus monkeys.
Publication types
-
Comparative Study
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Central Nervous System / metabolism
-
Dynorphins / analogs & derivatives
-
Dynorphins / cerebrospinal fluid
-
Dynorphins / metabolism
-
Endorphins / cerebrospinal fluid
-
Endorphins / metabolism
-
Enkephalin, Methionine / cerebrospinal fluid
-
Enkephalin, Methionine / metabolism
-
Macaca / physiology*
-
Macaca fascicularis / physiology
-
Macaca mulatta / physiology
-
Nerve Tissue Proteins / metabolism*
-
Radioimmunoassay
-
Receptors, Opioid / physiology*
-
Species Specificity
-
Substance P / cerebrospinal fluid
-
Substance P / metabolism
Substances
-
Endorphins
-
Nerve Tissue Proteins
-
Receptors, Opioid
-
Substance P
-
Enkephalin, Methionine
-
Dynorphins
-
rimorphin