Opiate receptors, neuropeptides in CNS and CSF of two Macaca species with different responsiveness to opiates

Eur J Pharmacol. 1986 Mar 11;122(1):143-7. doi: 10.1016/0014-2999(86)90171-8.

Abstract

Of two related Macaca species, the rhesus (M. mulatta), acquires opiate tolerance and dependence more readily than the cynomolgus (M. fascicularis). In the cynomolgus, mu-opiate receptors were significantly fewer in the caudate nucleus and globus pallidus; delta-sites were fewer in the thalamus. kappa-Sites showed no species difference. The levels of [Met5]enkephalin, substance P and dynorphin B in various brain areas were comparable. On the other hand, receptor-assayed endorphin activity was higher in CSF of cynomolgus than rhesus monkeys.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Central Nervous System / metabolism
  • Dynorphins / analogs & derivatives
  • Dynorphins / cerebrospinal fluid
  • Dynorphins / metabolism
  • Endorphins / cerebrospinal fluid
  • Endorphins / metabolism
  • Enkephalin, Methionine / cerebrospinal fluid
  • Enkephalin, Methionine / metabolism
  • Macaca / physiology*
  • Macaca fascicularis / physiology
  • Macaca mulatta / physiology
  • Nerve Tissue Proteins / metabolism*
  • Radioimmunoassay
  • Receptors, Opioid / physiology*
  • Species Specificity
  • Substance P / cerebrospinal fluid
  • Substance P / metabolism

Substances

  • Endorphins
  • Nerve Tissue Proteins
  • Receptors, Opioid
  • Substance P
  • Enkephalin, Methionine
  • Dynorphins
  • rimorphin