[Studies on evaluation of sustained release tablets of extracts of Ginkgo biloba releasing rate in vitro by pharmacological indicatrix]

Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(14):2292-6.
[Article in Chinese]

Abstract

Using sustained release tablets of Ginkgo bibolia extract as model drug,discuss technical feasibility of using biotic index to evaluate sustained release tablets. Chosing two pharmacological indicatrix: antioxidant ability and inhibition of platelet aggregation, to investigate the influence factors on experimental result, optimize the method and experiment condition, and set up pharmacological indicatrix evaluation method. Using those methods to determinate biological effects of dissolved liquid. Drawing release curves and biological effects curves, discussing their correlation. A good correlation was observed, illustrating that pharmacological indicatrix could evaluate sustained release tablets.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / chemistry
  • Delayed-Action Preparations
  • Female
  • Ginkgo biloba / chemistry*
  • Male
  • Plant Extracts / administration & dosage*
  • Plant Extracts / chemistry*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / chemistry
  • Rabbits
  • Tablets

Substances

  • Antioxidants
  • Delayed-Action Preparations
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Tablets