Cladieunicellins K and L, new eunicellin-based diterpenoids from an octocoral Cladiella sp

Fu-Yuan Shih; Tsung-Hung Chen; Mei-Chin Lu; Wu-Fu Chen; Zhi-Hong Wen; Yueh-Hsiung Kuo; Ping-Jyun Sung

doi:10.3390/ijms141121781

Cladieunicellins K and L, new eunicellin-based diterpenoids from an octocoral Cladiella sp

Int J Mol Sci. 2013 Nov 4;14(11):21781-9. doi: 10.3390/ijms141121781.

Authors

Fu-Yuan Shih¹, Tsung-Hung Chen, Mei-Chin Lu, Wu-Fu Chen, Zhi-Hong Wen, Yueh-Hsiung Kuo, Ping-Jyun Sung

Affiliation

¹ Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. kuoyh@mail.cmu.edu.tw.

Abstract

Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2 exhibited moderate cytotoxicity towards the MOLT-4 human leukemia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification*
Humans
Leukemia / drug therapy
Leukemia / pathology
Magnetic Resonance Spectroscopy
Spectrum Analysis

Substances

Diterpenes
cladieunicellin K
cladieunicellin L
eunicellin