Fluorescence modification of the AAAA (4A) loop: toward a probe of the structural dynamics of the i-motif of the retinoblastoma gene

Chem Commun (Camb). 2014 Jan 4;50(1):52-4. doi: 10.1039/c3cc46619a.

Abstract

Systematic modification of the 4A loop region of the Rb gene with (Py)A fluorophore units allows discrimination of the fluorescence signals corresponding to structural dynamics from single-stranded to i-motif structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Nucleotide Motifs*
  • Retinoblastoma Protein / chemistry*
  • Retinoblastoma Protein / genetics*
  • Spectrometry, Fluorescence

Substances

  • Retinoblastoma Protein