Abstract
Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.
Keywords:
Asteraceae; Cytotoxicity; Eudesmane; Germacrane; Inula wissmanniana Hand.-Mazz.; NO production.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Algorithms
-
Animals
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Crystallography, X-Ray
-
Drug Screening Assays, Antitumor
-
Hep G2 Cells
-
Humans
-
Inula / chemistry*
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Mice
-
Molecular Conformation
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Nuclear Magnetic Resonance, Biomolecular
-
Sesquiterpenes, Eudesmane / chemistry
-
Sesquiterpenes, Eudesmane / isolation & purification*
-
Sesquiterpenes, Eudesmane / pharmacology*
-
Sesquiterpenes, Germacrane / chemistry
-
Sesquiterpenes, Germacrane / isolation & purification*
-
Sesquiterpenes, Germacrane / pharmacology*
Substances
-
Antineoplastic Agents, Phytogenic
-
Lipopolysaccharides
-
Sesquiterpenes, Eudesmane
-
Sesquiterpenes, Germacrane
-
Nitric Oxide