Objective: To compare the diagnostic potential of ultrasonographic markers of ovarian morphology, used alone or in combination, to predict polycystic ovary syndrome (PCOS).
Design: A diagnostic test study using cross-sectional data collected from 2006-2011.
Setting: Academic hospital and clinical research unit.
Patient(s): Eighty-two women with PCOS and 60 healthy female volunteers.
Intervention(s): None.
Main outcome measure(s): Follicle number per ovary (FNPO), ovarian volume (OV), follicle number per single cross-section (FNPS), follicle distribution pattern, stromal area, ovarian area, stromal-to-ovarian area ratio (S:A), and stromal index (SI).
Result(s): Follicle number per ovary best predicted PCOS (R(2) = 67%) with 85% sensitivity and 98% specificity, followed by OV (R(2) = 44%), and FNPS (R(2) = 36%). Neither S:A nor SI had predictive power for PCOS. In combination, FNPO+S:A and FNPO+SI most significantly predicted PCOS (R(2) = 74% vs. 73%, respectively). The diagnostic potentials of OV and FNPS were substantially improved when used in combination (OV+FNPO, R(2) = 55%).
Conclusion(s): As a single metric, FNPO best predicted PCOS. Although the addition of S:A or SI improved the predictive power of FNPO, gains were marginal, suggesting limited use in clinical practice. When image quality precludes a reliable estimation of FNPO, measurements of OV+FNPS provide the next closest level of diagnostic potential.
Keywords: Polycystic ovary syndrome; follicle; hyperandrogenism; stroma; ultrasound.
Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.