The connection of temperament with depression is manifested especially as an accentuated feature of avoidance of problems. Personality disorders lead to aberrant ways to make observations of oneself and other people, to control feelings and get along with other people. A personality disorder significantly worsens the prognosis of depression so that compared with mere depression, recovery is slower and recurrence more likely. We discuss the connection of adulthood temperament features, personality and personality disorders with depression.