Analgesia in patients undergoing thoracotomy: epidural versus paravertebral technique. A randomized, double-blind, prospective study

J Thorac Cardiovasc Surg. 2014 Jan;147(1):469-73. doi: 10.1016/j.jtcvs.2013.09.024. Epub 2013 Nov 1.

Abstract

Background: Pain control after thoracotomy prevents postsurgical complications and improves respiratory function. The gold standard for post-thoracotomy analgesia is the epidural catheter. The aim of this study was to compare it with a new technique that involves placement of a catheter in the paravertebral space at the end of surgery under a surgeon's direct vision.

Methods: From November 2011 to June 2012, 52 patients were randomized into 2 groups depending on catheter placement: an epidural catheter for group A and a paravertebral catheter for group B. At 12, 24, 48, and 72 hours after surgery, the following parameters were recorded: (1) pain control using the patient's completion of a visual analog scale module, (2) respiratory function using forced expiratory volume in 1 second and ambient air saturation, and (3) blood cortisol values as an index of systemic reaction to pain.

Results: Statistically significant differences (P < .05) were found in favor of group B for both cough and rest pain control (P = .002 and .002, respectively) and respiratory function in terms of forced expiratory volume in 1 second and ambient air saturation levels (P = .023 and .001, respectively). No statistically significant differences were found in blood cortisol trends between the 2 groups (P > .05). Collateral effects such as vomiting, nausea, low pressure, or urinary retention were observed only in group A. No collateral effects were recorded in the paravertebral group.

Conclusions: According to our data, drugs administered through a paravertebral catheter are very effective. Moreover, it does not present contraindications to its positioning or collateral effects. More studies are necessary to confirm data we collected.

Keywords: 1; 11; 14; 5; EA; FEV1; PA; VAS; epidural anesthesia; forced expiratory volume in 1 second; paravertebral anesthesia; visual analog scale.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analgesia, Epidural / adverse effects
  • Analgesia, Epidural / methods*
  • Biomarkers / blood
  • Catheterization / adverse effects
  • Catheterization / methods*
  • Double-Blind Method
  • Epidural Space
  • Female
  • Forced Expiratory Volume
  • Humans
  • Hydrocortisone / blood
  • Italy
  • Lung / drug effects
  • Lung / physiopathology
  • Male
  • Middle Aged
  • Nerve Block / adverse effects
  • Nerve Block / methods*
  • Pain Measurement
  • Pain, Postoperative / blood
  • Pain, Postoperative / diagnosis
  • Pain, Postoperative / physiopathology
  • Pain, Postoperative / prevention & control*
  • Prospective Studies
  • Respiration / drug effects
  • Thoracotomy / adverse effects*
  • Time Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • Hydrocortisone