Guiding principles of subcutaneous immunotherapy for allergic rhinitis in Japan

Yoshitaka Okamoto; Nobuo Ohta; Mitsuhiro Okano; Atsushi Kamijo; Minoru Gotoh; Motohiko Suzuki; Sachio Takeno; Tetsuya Terada; Toyoyuki Hanazawa; Shigetoshi Horiguchi; Kohei Honda; Shoji Matsune; Takechiyo Yamada; Atsushi Yuta; Takeo Nakayama; Shigeharu Fujieda

doi:10.1016/j.anl.2013.06.003

Guiding principles of subcutaneous immunotherapy for allergic rhinitis in Japan

Auris Nasus Larynx. 2014 Feb;41(1):1-5. doi: 10.1016/j.anl.2013.06.003. Epub 2013 Nov 1.

Authors

Yoshitaka Okamoto¹, Nobuo Ohta², Mitsuhiro Okano³, Atsushi Kamijo⁴, Minoru Gotoh⁵, Motohiko Suzuki⁶, Sachio Takeno⁷, Tetsuya Terada⁸, Toyoyuki Hanazawa⁹, Shigetoshi Horiguchi¹⁰, Kohei Honda¹¹, Shoji Matsune¹², Takechiyo Yamada¹³, Atsushi Yuta¹⁴, Takeo Nakayama¹⁵, Shigeharu Fujieda¹³

Affiliations

¹ Chiba University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan. Electronic address: yokamoto@faculty.chiba-u.jp.
² Yamagata University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
³ Okayama University, Department of Otorhinolaryngology, Japan.
⁴ Saitama Medical University, Department of Otorhinolaryngology/Allergy Center, Japan.
⁵ Nippon Medical School, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
⁶ Nagoya City University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
⁷ Hiroshima University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
⁸ Osaka Medical University, Department of Otorhinolaryngology, Japan.
⁹ Chiba University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
¹⁰ Iida Hospital, Departments of Otorhinolaryngology and Allergology, Japan.
¹¹ Akita University, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
¹² Nippon Medical School, Department of Otorhinolaryngology, Musashikosugi Hospital, Japan.
¹³ University of Fukui, Department of Otorhinolaryngology and Head and Neck Surgery, Japan.
¹⁴ Yuta Clinic, Japan.
¹⁵ Department of Health Informatics, Kyoto University School of Public Health, Japan.

PMID: 24183858
DOI: 10.1016/j.anl.2013.06.003

Abstract

Objective: In anticipation of the development of guidelines for antigen-specific subcutaneous immunotherapy (SCIT), we present recommendations that can serve as guiding principles based on a review of the scientific literature.

Methods: Clinical questions (CQs) concerning SCIT were prepared. Literature searches for publications between January 1990 and February 2011 were performed in PubMed, the Cochrane Library, and Japana Centra Revuo Medicina Web version 4. Qualified studies were analyzed and the results were evaluated, consolidated, and codified.

Results: We present answers for 13 CQs on the indications, methods, effectiveness and mechanisms of SCIT, with evidence-based recommendations.

Conclusion: The guiding principles are intended to be applied to children (≤15 years old) and adults (≥16 years old) with allergic rhinitis (AR). These principles can be used by otorhinolaryngologists for diagnosis of AR, evaluation of severity and rhinoscopic findings, performance of antigen challenge tests, and management of systemic anaphylactic reactions associated with SCIT.

Keywords: Allergic rhinitis; Guideline; Principles; Subcutaneous immunotherapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Allergens / therapeutic use*
Desensitization, Immunologic / methods*
Humans
Injections, Subcutaneous
Japan
Practice Guidelines as Topic*
Rhinitis, Allergic
Rhinitis, Allergic, Perennial / therapy*
Treatment Outcome

Substances

Allergens