Effect of prenatal programming on heifer development

Vet Clin North Am Food Anim Pract. 2013 Nov;29(3):517-36. doi: 10.1016/j.cvfa.2013.07.001. Epub 2013 Aug 12.

Abstract

In beef cattle, the main factors influencing nutrient partitioning between the dam and fetus include age of the dam, number of fetuses, production demand, and environmental stress. These factors play a critical role in programming the fetus for its future environment and available resources. Fetal programming reportedly affects neonatal mortality and morbidity, postnatal growth rate, body composition, health, and reproduction. Two main mechanisms responsible for fetal programming include DNA methylation and histone modifications. Alterations in the genome can be passed through multiple generations. Maternal environment (nutrition, age, physiologic status) can program progeny heifer growth and reproductive performance.

Keywords: Beef cow; Epigenetic modification; Fetal programming; Maternal nutrition.

MeSH terms

  • Animal Husbandry / methods*
  • Animals
  • Cattle / embryology
  • Cattle / growth & development
  • Cattle / physiology*
  • Female
  • Fetal Development / genetics
  • Fetal Development / physiology*
  • Pregnancy
  • Reproduction / genetics
  • Reproduction / physiology*