Abstract
Seven new 3,4,6-trisubstituted α-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Aspergillus niger / drug effects
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Bacillus subtilis / drug effects
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Candida albicans / genetics
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Feces / microbiology*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Hylobates / microbiology*
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Microbial Sensitivity Tests
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Molecular Structure
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Pseudomonas aeruginosa / drug effects
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
Substances
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Anti-Bacterial Agents
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Pyrones