Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

Natsuhisa Oka; Yasuhiro Morita; Yuta Itakura; Kaori Ando

doi:10.1039/c3cc46617e

Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

Chem Commun (Camb). 2013 Dec 21;49(98):11503-5. doi: 10.1039/c3cc46617e.

Authors

Natsuhisa Oka¹, Yasuhiro Morita, Yuta Itakura, Kaori Ando

Affiliation

¹ Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. oka@gifu-u.ac.jp.

PMID: 24177564
DOI: 10.1039/c3cc46617e

Abstract

Inosine derivatives bearing a phosphodiester group at the O(6)-position of the nucleobase were synthesized via phosphitylation of the carbonyl oxygen using phosphoramidites activated by non-nucleophilic acidic activators.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aziridines / chemistry
Esters / chemistry
Hypoxanthine / chemistry
Inosine Nucleotides / chemistry*
Mesylates / chemistry
Oxygen / chemistry

Substances

Aziridines
Esters
Inosine Nucleotides
Mesylates
Hypoxanthine
Oxygen