[18F]fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates

Kiran B Gona; Vanessa Gómez-Vallejo; Daniel Padro; Jordi Llop

doi:10.1039/c3cc46695g

[18F]fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates

Chem Commun (Camb). 2013 Dec 21;49(98):11491-3. doi: 10.1039/c3cc46695g.

Authors

Kiran B Gona¹, Vanessa Gómez-Vallejo, Daniel Padro, Jordi Llop

Affiliation

¹ Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramón 182, Parque Tecnológico de San Sebastian, 20009, San Sebastian, Spain. jllop@cicbiomagune.es.

PMID: 24175318
DOI: 10.1039/c3cc46695g

Abstract

The mono-[(18)F]fluorination of o-carborane via nucleophilic substitution is reported. The new radiochemical transformation uses cyclotron produced [(18)F]F(-) and a carboranyl iodonium salt. Further derivatization of the (18)F-labelled carborane is achieved by formation of the C(c)-lithio salt and reaction with an aldehyde.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds / chemistry*
Boron Neutron Capture Therapy
Cyclotrons
Fluorine Radioisotopes / chemistry*
Radiopharmaceuticals / chemistry*

Substances

Boron Compounds
Fluorine Radioisotopes
Radiopharmaceuticals