1H, 13C NMR studies of new 3-aminophenol isomers linked to pyridinium salts

Magn Reson Chem. 2014 Jan-Feb;52(1-2):40-6. doi: 10.1002/mrc.4025. Epub 2013 Oct 30.

Abstract

(1)H and (13)C NMR spectroscopic data of 20 new non-symmetrical compounds were assigned by a combination of 1D and 2D NMR experiments (DEPT, HSQC, and HMBC). These compounds contain a 4-(N,N-dimethylamino)- or 4-(pyrrolidin-1-yl)pyridinium moiety and a 3-nitro-, 3-amino-, or 3-hydroxyphenyl ring, linked by p-xylene, 4,4'-dimethylbiphenyl, 1,2-bis(p-tolyl)ethane, or 1,4-bis(p-tolyl)butane.

Keywords: 1H-13C 1D NMR; 1H-13C 2D NMR (HSQC; HMBC); antiproliferative compounds; choline kinase inhibitors.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminophenols / chemistry*
  • Carbon Isotopes / analysis
  • Isomerism
  • Magnetic Resonance Spectroscopy / methods*
  • Protons
  • Pyridinium Compounds / chemistry*
  • Salts / chemistry

Substances

  • Aminophenols
  • Carbon Isotopes
  • Protons
  • Pyridinium Compounds
  • Salts
  • 3-aminophenol