Targeting metabolic scavenging in pancreatic cancer

Clin Cancer Res. 2014 Jan 1;20(1):6-8. doi: 10.1158/1078-0432.CCR-13-2570. Epub 2013 Oct 28.

Abstract

Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Acrylamides / pharmacology*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Female
  • Humans
  • NAD / metabolism*
  • Pancreatic Neoplasms / drug therapy*
  • Piperidines / pharmacology*

Substances

  • Acrylamides
  • Antineoplastic Agents
  • N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
  • Piperidines
  • NAD