Abstract
Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Acrylamides / pharmacology*
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Animals
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Antineoplastic Agents / pharmacology*
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Female
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Humans
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NAD / metabolism*
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Pancreatic Neoplasms / drug therapy*
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Piperidines / pharmacology*
Substances
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Acrylamides
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Antineoplastic Agents
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N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
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Piperidines
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NAD