DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications

Pierpaolo Falcicchio; Suzanne Wolterink-Van Loo; Maurice C R Franssen; John van der Oost

doi:10.1007/s00792-013-0593-x

DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications

Extremophiles. 2014 Jan;18(1):1-13. doi: 10.1007/s00792-013-0593-x. Epub 2013 Oct 29.

Authors

Pierpaolo Falcicchio¹, Suzanne Wolterink-Van Loo, Maurice C R Franssen, John van der Oost

Affiliation

¹ Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703HB, Wageningen, The Netherlands, pierpaolo.falcicchio@wur.nl.

PMID: 24166576
DOI: 10.1007/s00792-013-0593-x

Abstract

Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed.

Publication types

Review

MeSH terms

Aldehyde-Lyases / chemistry*
Aldehyde-Lyases / classification
Aldehyde-Lyases / metabolism
Archaeal Proteins / chemistry*
Archaeal Proteins / classification
Archaeal Proteins / metabolism
Bacterial Proteins / chemistry*
Bacterial Proteins / classification
Bacterial Proteins / metabolism
Dihydroxyacetone Phosphate / chemistry
Dihydroxyacetone Phosphate / metabolism
Enzyme Stability
Hot Temperature*

Substances

Archaeal Proteins
Bacterial Proteins
Dihydroxyacetone Phosphate
Aldehyde-Lyases