A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

Org Biomol Chem. 2013 Dec 21;11(47):8241-6. doi: 10.1039/c3ob41440j. Epub 2013 Oct 28.

Abstract

A copper-catalysed oxidative amidation of aldehydes via N-hydroxysuccinimide ester formation is reported. The methodology employed to prepare amides directly from aldehydes has a very wide scope, is high yielding, and does not need dry conditions. This cross-coupling reaction appears to be simple and makes use of cheap, abundant and easily available reagents.