Rhodium(III)-catalyzed direct regioselective synthesis of 7-substituted indoles

Org Lett. 2013 Nov 15;15(22):5662-5. doi: 10.1021/ol402626t. Epub 2013 Oct 28.

Abstract

An efficient, atom-economic one-pot method was developed for the preparation of 7-substituted indoles via rhodium(III)-catalyzed oxidative cross-coupling. Regioselective olefination of indoline derivatives followed by one-pot subsequent oxidation provided the desired products in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Catalysis
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Indoles
  • indoline
  • Rhodium