Abstract
The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acoustic Stimulation
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Action Potentials / physiology
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Animals
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Cerebellum / cytology*
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Channelrhodopsins
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Dependovirus / genetics
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Functional Laterality
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Gene Expression Regulation / physiology
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Learning / physiology*
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Luminescent Proteins / genetics
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Luminescent Proteins / metabolism
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Mice
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Mice, Transgenic
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Motor Activity / genetics
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Motor Activity / physiology*
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Motor Skills / physiology*
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Mutation / genetics
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Optogenetics
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Photic Stimulation
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Purkinje Cells / physiology*
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Transduction, Genetic
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Vestibule, Labyrinth / physiology
Substances
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Channelrhodopsins
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Luminescent Proteins