Abstract
Propofol (2,6-diisopropylphenol) is a commonly used short-acting intravenous anesthetic agent. However, because of the risk of drug abuse and propofol related death, in Korea propofol is a controlled drug. In this review, the analytical methods using liquid chromatography (LC), gas chromatography/mass spectrometry, or LC coupled with tandem mass spectrometry to detect and quantify propofol or its metabolites in blood were described. The validation data for the analytical methods and propofol concentrations in the blood were reviewed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anesthetics, Intravenous / blood*
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Chromatography, High Pressure Liquid / instrumentation
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Chromatography, High Pressure Liquid / methods*
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Gas Chromatography-Mass Spectrometry / instrumentation
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Gas Chromatography-Mass Spectrometry / methods*
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Humans
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Limit of Detection
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Propofol / blood*
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Reproducibility of Results
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Republic of Korea
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Substance Abuse Detection / legislation & jurisprudence
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Substance Abuse Detection / methods*
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Tandem Mass Spectrometry / instrumentation
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Tandem Mass Spectrometry / methods*
Substances
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Anesthetics, Intravenous
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Propofol