Abstract
In this study, the effect of low-molecular weight white ginseng compounds on various biochemical indices, including blood lipid concentrations and antioxidant enzyme activities and morphological changes was investigated in rabbits with high cholesterol diet-induced hypercholesterolemia. The experimental animals were 16-week-old male New Zealand white rabbits divided into normal control diet, high cholesterol diet, and high cholesterol with 0.05% white ginseng low-molecule compound groups, treated for 4 weeks. Blood lipid concentrations were higher in the high cholesterol groups compared to the normal control group but were not improved by the white ginseng low-molecular weight compound. We note however that antioxidant enzyme activities and morphological changes of the aorta showed that white ginseng small compounds had a positive effect on hypercholesterolemia. Based on such results, low-molecular weight compounds rich in phenolic compounds in white ginseng can be said to be effective in part in improving hyperlipidemia and atherosclerosis induced by a high cholesterol diet among New Zealand white rabbits.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticholesteremic Agents / isolation & purification
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Anticholesteremic Agents / pharmacology*
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Anticholesteremic Agents / therapeutic use
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Antioxidants / therapeutic use
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Aorta / drug effects
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Aorta / pathology
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Atherosclerosis / drug therapy*
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Atherosclerosis / etiology
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Atherosclerosis / pathology
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Catalase / metabolism
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Cholesterol, Dietary / administration & dosage*
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Glutathione Peroxidase / metabolism
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Glutathione Transferase / metabolism
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Hypercholesterolemia / blood
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Hypercholesterolemia / drug therapy*
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Hypercholesterolemia / etiology
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Lipid Peroxidation / drug effects
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Lipids / blood
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Liver / drug effects
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Liver / enzymology
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Male
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Panax / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology
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Phenols / therapeutic use
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rabbits
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Superoxide Dismutase / metabolism
Substances
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Anticholesteremic Agents
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Antioxidants
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Cholesterol, Dietary
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Lipids
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Phenols
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Plant Extracts
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Catalase
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Glutathione Peroxidase
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Superoxide Dismutase
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Glutathione Transferase