Red algal bromophenols as glucose 6-phosphate dehydrogenase inhibitors

Daisuke Mikami; Hideyuki Kurihara; Sang Moo Kim; Koretaro Takahashi

doi:10.3390/md11104050

Red algal bromophenols as glucose 6-phosphate dehydrogenase inhibitors

Mar Drugs. 2013 Oct 22;11(10):4050-7. doi: 10.3390/md11104050.

Authors

Daisuke Mikami¹, Hideyuki Kurihara, Sang Moo Kim, Koretaro Takahashi

Affiliation

¹ Faculty and Graduate School of Fisheries Sciences, Hokkaido University, Minato, Hakodate, Hokkaido 041-8611, Japan. kuri@fish.hokudai.ac.jp.

Abstract

Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glucosephosphate Dehydrogenase / antagonists & inhibitors*
Laurencia / chemistry*
Phenolsulfonphthalein / analogs & derivatives*
Phenolsulfonphthalein / pharmacology
Rhodophyta / chemistry*

Substances

bromophenol red
Glucosephosphate Dehydrogenase
Phenolsulfonphthalein