Mammalian cardiolipin biosynthesis

Edgard M Mejia; Hieu Nguyen; Grant M Hatch

doi:10.1016/j.chemphyslip.2013.10.001

Mammalian cardiolipin biosynthesis

Chem Phys Lipids. 2014 Apr:179:11-6. doi: 10.1016/j.chemphyslip.2013.10.001. Epub 2013 Oct 19.

Authors

Edgard M Mejia¹, Hieu Nguyen¹, Grant M Hatch²

Affiliations

¹ Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
² Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of Biochemistry and Medical Genetics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada. Electronic address: ghatch@mich.ca.

PMID: 24144810
DOI: 10.1016/j.chemphyslip.2013.10.001

Abstract

Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis and provide an overview of regulation of cardiolipin biosynthesis. In addition, the important role that this key phospholipid plays in disease processes including heart failure, diabetes, thyroid hormone disease and the genetic disease Barth Syndrome will be discussed.

Keywords: Barth Syndrome; Cardiolipin; Diabetes; Genetic disease; Heart failure; Lipid; Metabolism; Mitochondria; Phospholipid; Thyroid hormone.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiolipins / biosynthesis*
Cardiolipins / metabolism
Disease
Humans
Mammals / metabolism*

Substances

Cardiolipins